Radiopacidad de Materiales Utilizados Como Sustituto Dentinario / Radiopacity of Materials Used as Dentin Substitutes

El objetivo de este estudio fue comparar la radiopacidad de distintos materiales utilizados como sustitutos de la dentina según norma ISO 6876. Se utilizaron Biodentine-Septodont (a base de silicato de calcio), Equia Forte ­ GC Corporation (ionómero vítreo convencional), Sure Fill SDR Flow ­ Dentsply Sirona (composite bulk-fill), MTA Densell Reparative - Densell (a base de silicato de calcio). Se confeccionaron 12 probetas cilíndricas, tres por cada material, siguiendo las instrucciones de los respectivos fabricantes y se colocaron en estufa a 37°C durante su fraguado. Se tomaron radiografías oclusales digitales junto a una cuña de aluminio graduada según norma ISO 6876. En cada imagen se determinaron los valores de L de la escala CieLab (negro-blanco) con el programa Photoshop (Adobe). Los resultados se analizaron estadísticamente mediante ANOVA y prueba de Tukey (AU)

A novel homozygous mutation in the solute carrier family 12 member 3 gene in a Chinese family with Gitelman syndrome

Loss of function of mutated solute carrier family 12 member 3 (SLC12A3) gene is the most frequent etiology for Gitelman syndrome (GS), which is mainly manifested by hypokalemia, hypomagnesemia and hypocalciuria. We report the genetic characteristics of one suspicious Chinese GS pedigree by gene sequencing. Complete sequencing analysis of the SLC12A3 gene revealed that both the proband and his elder sister had a novel homozygous SLC12A3 mutation: c.2099T>C and p.Leu700Pro. Moreover, the SLC12A3 genes of his mother and daughter encoded the same mutated heterozygote. It was noted that in this pedigree, only the proband complained about recurrent episodes of bilateral lower limb weakness over 8 years, while his elder sister, mother and daughter did not present symptoms. The inconsistent clinical features of this pedigree implied that besides diverse phenotypes possibly originated from the same genotype, gender difference may also dominate the variant GS phenotypes. Further genetic and proteomic research are needed to investigate the precise mechanisms of GS, including the study of specific ethnicities.

Utilizing Levine's conservation model in the care of patient with lithium toxicity: Caring beyond the symptoms

@#<p style="text-align: justify;">Health  professionals  are  trained  to  recognize  and  address  cues  which  endanger  the  client's survival. In critical situations, we focus on ensuring the airway, breathing and circulation (ABC) in order to sustain life. Oftentimes, we feel great in performing dramatic interventions and save our patients from the brink of death. But is this enough? Does our role end here? Is this only how we define good nursing care?<br />This is the case of DL, a 39 year old female who, upon admission to the pay ward in Philippine General  Hospital,  presented  with  respiratory  distress,  as  evidenced  by  dyspnea  and  oxygen desaturation, necessitating intubation. Health history revealed the client as a diagnosed case of Bipolar  I  Disorder  for  21  years.  The  goal  of  providing  holistic  care  to  a  patient  with  a  mood-affective disorder presenting with a medical emergency, like DL, poses a crucial challenge - the challenge in going beyond what meets the eye and focusing on human responses and not just the disease process. This case was then selected to serve as a reminder and a learning opportunity that we should not be limited to symptom management, but more importantly, to recognize the totality of the human being, which is the true essence of nursing care. </p>